Bu aragtirmada ikiuglu duygudurum bozuklugu hastalanyla ruh- sal hastahk oykiisu bulunmayan saglikh kontrol grubu arasmda HLA antijenlerinin sikligi kargilagtirilmigtir. Iki uglu duygudurum bozuklugu tamsi DSM-III-R olgiitlerine gore konmugtur. 50 ikiug- lu duygudurum bozuklugu hastasi He 100 kigi kontrol grubunda HLA A, B, C, DR ve DQ antijenlerinin sikligi kargilagtirilmigtir. HLA B7, DR11 ve DQ 7 antijenlerine ikiuglu duygudurum bozuklugu grubunda daha sik rastlanmigtir. Bu sonuglar en azmdan bazi HLA antijenlerinin duygudurum bozukluklariyla iligkili ola- bilecegini dugundurmektedir.
Anahtar Kelimeler: Anahtar Sozciikler: Genetik, HLA, ikiuglu duygudurum bozuklugu, tip 1.This study compared the frequencies of HLA antigens of subjects with bipolar disorder to subjects with no history of any mental illness. Diagnoses were rendered according to DSM-III-R criteria. A total of 50 bipolar I subjects were compared to 100 never-ill subjects on HLA loci A, B, C, DR, DQ. In bipolar I patients, antigens of HLA B7, DR 11 and DQ7 were more frequent than control group. These findings indicate that at least some HLA antigens might be related to bipolar disorder.
Keywords: Key Words: Genetics, HLA, bipolar mood disorder, type 1.