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GÝRÝÞ ve AMAÇ: Sýkýntý toleransý ve Rahatsýzlýk toleransý, birbirleriyle iliþkili ancak farklýlýklarý olan yerleþik psikolojik kavramlardýr. Sýkýntý toleransý, bireyin olumsuz duygusal durumlara dayanma algýsý veya olumsuz etki baðlamýnda hedefe yönelik davranýþý sürdürme kapasitesi olarak tanýmlanýr. Rahatsýzlýk toleransý ise esas olarak olumsuz bedensel hislere dayanma kapasitesi ile ilgilidir. Bedensel ve psikolojik semptomlardan oluþan premenstrüel disforik bozukluk (PMDB), DSM-5’e göre depresif bozukluklar kategorisindedir. Bu araþtýrma makalesinde premenstrüel disforik bozukluðun sýkýntýya ve rahatsýzlýða dayanma düzeylerine olan olasý etkilerini ve bu bireylerdeki fonksiyonel olmayan tutumlarý araþtýrdýk.
YÖNTEM ve GEREÇLER: Çalýþmamýzda toplam 218 kiþi ile görüþme yapýldý. Adet Öncesi Belirtileri Tarama Gereci (AÖBTG)’ne göre PMDB olabilecek kiþiler 8 hafta boyunca izlendi ve 31 kiþi PMDB tanýsý aldý. Bu kiþiler ile yaþ ve vücut kitle indeksi (VKÝ) olarak eþleþen, AÖBTG’ye göre eþik altý belirtilerine sahip olanlar ve PMDB’a sahip olmayanlar çalýþmamýza dahil edildi. Her bir örnek için Sýkýntýya Dayanma Ölçeði (SDÖ), Rahatsýzlýða Dayanma Ölçeði (RDÖ), Fonksiyonel Olmayan Tutumlar Ölçeði- kýsa formu (FOTÖ-kf) dolduruldu.

BULGULAR: Sýkýntýya Dayanma Ölçeði’nin öz yeterlilik alt puanlarý; PMDB olmayan grupta, PMDB olan grupta ve eþik altý belirtilere sahip olan gruptakilere göre daha yüksek bulundu. FOTÖ-kf’nun toplam puaný PMDB olanlarda, PMDB olmayan ve eþik belirtilere sahip olan gruptakilere göre daha yüksek saptandý. PMDB olanlarda RDÖ’nin rahatsýzlýktan kaçýnma alt puaný, PMDB olmayanlara ve eþik altý belirtilere sahip olanlara göre daha yüksek saptandý.
TARTIÞMA ve SONUÇ: Sonuç olarak PMDB’u olan kadýnlar, rahatsýzlýktan kaçýnma davranýþlarýný en aza indiren ve premenstrual sendromun olumsuz bedensel duyumlarý ile baþ etmelerini kolaylaþtýracak ve bu bedensel ve ruhsal olan rahatsýz edici duyumlara yönelik fonksiyonel olmayan tutumlarýn geliþmesini önleyen koruyucu tedavi modalitelerinden yararlanabilirler.

INTRODUCTION: Distress tolerance and Discomfort tolerance are well-established psychological constructs that are related but distinct. Distress tolerance is defined as an individual’s perceived capacity to withstand negative emotional states or the capacity to continue goal-directed behavior in the context of negative affect. As for discomfort tolerance, it mainly is about the capacity to withstand negative bodily sensations. Premenstrual dysphoric disorder (PMDD) which consists of bodily and psychological symptoms is a DSM-5 diagnosed disease determined under the category of depressive disorders.In this research article, we investigated the possible effects of premenstrual dysphoric disorder on distress and discomfort tolerance levels as well as dysfunctional attitudes on individuals with this disorder.

METHODS: In our study, 218 people were interviewed in total. People who could possibly have PMDD according to Premenstrual Symptoms Screening Tool (PSST) were monitored for 8 weeks and 31 people were diagnosed with PMDD. People without PMDD and having under threshold symptoms for PMDD according to PSST who have matching age and BMI were also included in the study. Distress Tolerance Scale (DTS), Discomfort Intolerance Scale (DIS), Dysfunctional Attitude Scale-short forms (DAS-sf) were filled for each sample.
RESULTS: DTS self-efficacy scores were found to be higher in group without PMDD than the groups with PMDD and having under threshold symptoms. DAS-total score was found to be higher in group with PMDD than the groups without PMDD group and having under threshold symptoms group. Discomfort avoidance subscale score of distress tolerance scale was found to be higher compared to participants without PMDD and participants having below threshold symptoms.
DISCUSSION AND CONCLUSION: Women with PMDD may benefit from preventive treatment modalities that minimize discomfort and avoidance behaviours and facilitate their coping with negative bodily sensations of premenstrual syndrome and prevent the development of dysfunctional attitudes toward these bodily and mental disturbing sensations.

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GÝRÝÞ ve AMAÇ: Alkol ve madde baðýmlýlýðýna yönelik yapýlan çalýþmalar, tarihsel olarak, kadýn hastalarý ihmal etmiþ ve sadece erkek hastalarda yapýlan çoðu çalýþmanýn sonuçlarý kadýn popülasyonuna genelleþtirilmiþtir. Bu çalýþmada, alkol/madde kullaným bozukluðu nedeniyle tedavi olmak üzere bir baðýmlýlýk polikliniðine baþvuran kadýn hastalarda, sosyodemografik özelliklerin, alkol/madde kullaným özelliklerinin, ek ruhsal hastalýklarýn ve tedavi ve izlem sonuçlarýnýn geriye dönük olarak incelenmesi amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Ege Üniversitesi Baðýmlýlýk Polikliniði’ne 1 Mayýs 2013 ile 31 Aðustos 2018 tarihleri arasýnda ardýþýk olarak baþvuran ve DSM 5’e göre alkol/madde kullaným bozukluðu tanýsý alan 68 kadýn olgunun dosyasý incelendi.
BULGULAR: Olgularýn %60.3’ünde alkol, %39.7’sinde madde kullaným bozukluðu mevcuttu. Madde kullaným bozukluðu tanýsý olanlarda aðýrlýklý olarak kullanýlan madde %44.4 ile çoðul madde idi. Alkol kullaným bozukluðu tanýlý olgularda sorunlu alkol kullanýmý süresi 8.3±7.8 yýl, madde kullaným bozukluðu tanýlý olgularda sorunlu madde kullanýmý süresi 7.6±5.4 yýldý. Alkol kullaným bozukluðu olan grubun sorunlu alkol kullanýmýna baþlama yaþý, madde kullaným bozukluðu olan grubun sorunlu madde kullanýmýna baþlama yaþýndan daha büyüktü (t=3.643, p=0.001). Tüm olgularýn %54.2’sinde depresif bozukluk mevcuttu. Olgularýn %70.5’i en azýndan 1 ay süreyle kontrole gelmiþ, en azýndan 1 ay süreyle kontrole gelen olgularýn %47.9’u idame tedavi almýþ ve kontrole geldiði süre boyunca %37.5’i tam ayýklýðý saðlamýþtý.
TARTIÞMA ve SONUÇ: Alkol/madde kullaným bozukluðu tanýlý kadýn hasta grubunda, sosyodemografik ve klinik özelliklerin deðerlendirildiði, ülkemizdeki en geniþ örneklemli bu çalýþmanýn bulgularý, kontrollü ve uzunlamasýna izlemli çalýþmalarla geliþtirilmeli ve desteklenmelidir.

INTRODUCTION: The studies on alcohol/drug addiction have historically neglected female patients and the results of most studies exclusively conducted on male patients have been generalized to include female population. This study aims to retrospectively investigate the sociodemographic characteristics, alcohol/drug consumption characteristics, comorbid mental illnesses, treatment and follow-up results in female patients who applied to an outpatient addiction clinic for the treatment of alcohol/drug use disorder.
METHODS: The patient files of the consecutive 68 women who visited Ege University Outpatient Addiction Clinic between May 1, 2013 and August 31, 2018 and were diagnosed with alcohol/drug use disorder according to DSM-5 were analyzed.
RESULTS: The findings revealed that 60.3% of patients had alcohol, 39.7% had drug use disorder. The drug mainly used by the ones diagnosed with drug use disorder was polydrug with a ratio of 44.4%. The duration of problematic alcohol use in the women diagnosed with alcohol use disorder was 8.3±7.8 years, the duration of problematic drug use in the women diagnosed with drug use disorder was 7.6±5.4 years. The age of onset of problematic alcohol use in the group with alcohol use disorder was higher than the age of onset of problematic drug use in the group with drug use disorder (t=3.643, p=0.001). Depressive disorder was observed in 54.2% of all patients. 70.5% of patients attended outpatient clinic follow-up at least for a period of 1 month, 47.9% of the patients who attended follow-up appointments at least for a period of 1 month received maintenance treatment and 37.5% of those maintained complete abstinence during that period.
DISCUSSION AND CONCLUSION: The findings of this study with the largest sample in our country where sociodemographic and clinical characteristics are evaluated in a group of female patients diagnosed with alcohol/drug use disorder should be developed and supported by controlled and longitudinal follow-up studies.

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GÝRÝÞ ve AMAÇ: Çalýþmanýn amacý, depresyon belirtileri ile geleceðe yönelik öngörüler ve yürütsel iþlevler arasýndaki iliþkileri incelemek; yürütsel iþlevler ile depresyon arasýndaki iliþkide geleceðe yönelik öngörülerin aracý rolünü belirlemektir.
YÖNTEM ve GEREÇLER: Beck Depresyon Envanteri, Kiþilerarasý Nörobiyoloji Temelli Yürütsel Ýþlevler Ölçeði ve Geleceðe Yönelik Öngörüler Ölçeði veri toplama araçlarý olarak kullanýlmýþtýr. Çalýþmanýn örneklemini, 235’i kadýn (%58.6) 166’sý erkek (%41.4) olmak üzere, 401 üniversite öðrencisi oluþturmuþtur. Yaþ aralýðý 18-31, yaþ ortalamasý 21.44’dür (ss= 2.33).
BULGULAR: Yapýlan istatistik analizler sonucunda, depresyon belirtileri ile geleceðe yönelik olumlu öngörüler arasýnda negatif, olumsuz öngörüler arasýnda ise pozitif iliþkilerin bulunduðu görülmektedir. Yürütsel iþlevler toplam puanlarý ile depresyon belirtileri arasýnda ise negatif bir iliþki söz konusudur. Buna ek olarak, aracý deðiþkenli regresyon analizi sonuçlarý yürütsel iþlevler ile depresyon belirtileri arasýndaki iliþkide geleceðe yönelik olumlu ve olumsuz öngörülerin aracýlýk rollerinin olduðunu göstermektedir.
TARTIÞMA ve SONUÇ: Elde edilen bulgular, depresyon tedavisi sýrasýnda psikoterapinin yapýlandýrýlmasýna katký saðlayabilir. Örneðin, terapi seanslarý esnasýnda hastanýn alýþýlmýþ tutumlara katý bir þekilde baðlýlýk, alternatif problem çözme yollarýný belirleyememe, katý açýklama tarzlarý ve biliþsel esneklikte zayýflama gibi yürütsel iþlevlerine yönelik özellikleri belirlenerek, bunlar üzerinde çalýþýlabilir. Ayrýca, bu seanslarda geleceðe iliþkin öngörülerin incelenmesi de yararlý olacaktýr.

INTRODUCTION: The aim of this study was to study the possible relationships between depressive symptoms, future expectations (i.e. prospections), and prefrontal functions. More specifically, the potential mediating effects of future expectations in the relationship between depressive symptoms and prefrontal functions were investigated.
METHODS: Data collection tools included Beck Depression Inventory, Prefrontal Functions Scale based on Interpersonal Neurobiology, and Subjective Probability Task – Turkish Version. Study sample included 401 undergraduate students, where 235 (58.6%) of those were female and 166 (41.4%) were male. Participants had an age range of 18-31, and the mean age was found to be 21.44 (sd = 2.33).
RESULTS: Statistical analyses revealed that as depression symptoms strengthen, there appears to be a corresponding decrease in the ratings for positive prospection, and a counter increase in the ratings for negative prospection (i.e. how likely they think such events will happen to them in the future). Furthermore, prefrontal functioning suffered a significant decline as depression scores increased. The mediated regression model further indicated that positive as well as negative prospections did indeed have partial mediating effects in regulating the relationship between depression scores and prefontal functioning.
DISCUSSION AND CONCLUSION: Results of the study are considered to be of possible value for the aim of structuring specific psychotherapy interventions. Identification of strictly held attitudes of clients, for instance, alongside with the inability to identify alternative solutions to problems encountered, strict reliance on specific explanations as causes behind them, or weakening cognitive flexibility, can be prioritized earlier in therapy and the following progress can, hence, be planned accordingly. Investigation of prospective thoughts can also be informative in this respect.

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GÝRÝÞ ve AMAÇ: Bu çalýþmanýn amacý bir çocuk ve ergen psikiyatrisi kliniðine baþvuran örgün eðitim sisteminden ayrýlmýþ olan ergenlerin psikiyatrik tanýlarýnýn daðýlýmýnýn ve anksiyete/depresyon düzeylerinin deðerlendirilmesidir.
YÖNTEM ve GEREÇLER: Çalýþmaya Mardin Devlet Hastanesi Çocuk Ergen Psikiyatrisi Kliniði’ ne baþvuran 12-18 yaþ arasý okulu býrakmýþ ergenler alýnmýþtýr. Hastalarýn psikiyatrik tanýlarý DSM-V’ e göre yapýlan klinik görüþme ile belirlenmiþtir. Ayrýca hastalara doldurmalarý için sosyodemografik veri formu, Çocuklar için Depresyon Ölçeði ve Spielberger Durumluk-Sürekli Kaygý Ölçeði verilmiþtir.
BULGULAR: Araþtýrmaya 54 ergen dahil edilmiþtir. Baþvuran hastalarýn yaþ ortalamasý 15,7 idi. DSM-V’ e göre yapýlan klinik görüþme sonucunda olgularda en sýk saptanan taný Dikkat Eksikliði Hiperaktivite Bozukluðu(DEHB)(n: 16, %29.6) olmuþtur. Bunu Depresif Bozukluklar(n: 12, %22.2) ve Anksiyete Bozukluklarý(n: 9, %16.6) izlemiþtir. Erkeklerde en sýk izlenen taný DEHB, kýzlarda ise Depresif Bozukluklardýr. Depresyon skorlarýnýn ortalamasý 21.8 puan ve 27(%58.7) hastanýn kesme puanýnýn üstünde olduðu, Durumsal Kaygý Ölçeði ortalamasý 48.1 puan ve Sürekli Kaygý Ölçeði ortalamasýnýn 50.8 puan olduðu görülmüþtür. Kesme puanlarýna göre yapýlan deðerlendirmede 36(%78.3) hastanýn durumsal kaygý seviyesinin yüksek olduðu, 35(%76.1) hastanýn sürekli kaygý seviyesinin yüksek olduðu bulunmuþtur.
TARTIÞMA ve SONUÇ: Okulu býrakan ergenlerde psikopatoloji oranlarý, depresyon/anksiyete düzeyleri yüksektir.

INTRODUCTION: The aim of this study was to determine the distribution of psychiatric diagnoses and anxiety / depression levels of adolescents who applied to a child and adolescent psychiatry department.
METHODS: The study included adolescents aged 12-18 years who applied the Child and Adolescent Psychiatry Department of Mardin State Hospital. The psychiatric diagnoses of the patients were determined by clinical interview according to DSM-V. Besides, sociodemographic data form, Children's Depression Inventory and Spielberger State-Trait Anxiety Inventory were filled to the patients.
RESULTS: 54 adolescents were included in the study. The mean age of the patients was 15.7 years old. According to DSM-V Attention Deficit Hyperactivity Disorder (ADHD) was found the most common diagnosis (n: 16, 29.6%). This was followed by Depressive Disorders (n: 12, 22.2%) and Anxiety Disorders (n: 9, 16.6%). The most common diagnosis is ADHD in boys and Depressive Disorders in girls. The mean depression score was 21.8 and 27 (58.7%) were above the cut-off score. The mean of the State Anxiety Scale found 48.1 and the mean of the Trait Anxiety Scale found 50.8. According to the cut-off scores, 36 (78.3%) of the patients had a high level of situational anxiety and 35 (76.1%) had a high level of trait anxiety.
DISCUSSION AND CONCLUSION: Psychopathology rates and depression / anxiety levels are high peers in adolescents who drop out of school.

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GÝRÝÞ ve AMAÇ: Þiddet önemli bir toplumsal sorundur ve ruh saðlýðý üzerinde de olumsuz etkileri bulunmaktadýr. Bu çalýþmada, psikiyatri polikliniðine baþvuran hastalarýn þiddeti nasýl tanýmladýklarýnýn, þiddete maruz kalma sýklýklarýnýn ve þiddetten etkilenme alanlarýnýn saptanmasý amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Çalýþmaya psikiyatri polikliniðine baþvuran ve çalýþmaya katýlmayý kabul eden 199 hasta dahil edildi. Hastalarýn sosyodemografik özellikleri ve þiddete yönelik ayrýntýlý deðerlendirmeleri, þiddetle ilgili literatür gözden geçirilerek araþtýrmacýlar tarafýndan hazýrlanan anket formu ile incelendi.
BULGULAR: Þiddet, çalýþmaya katýlan kadýnlarýn %78.9’u ve erkeklerin %75.5’i tarafýndan fiziksel olarak tanýmlandý. Her iki cinsiyet de þiddetin en sýk nedeninin "söz dinlenmemesi/sinirlendirici davranýþta bulunulmasý" olduðunu; þiddeti önleyebilecek etkenlerin baþýnda eðitimin olduðunu belirtti. Hastalarýn %56’sýnýn (kadýnlarýn %56.8’i, erkeklerin ise %55.9’u) þiddete maruz kaldýðý ve kadýnlarýn erkeklerden daha sýk cinsel þiddete maruz kaldýðý saptandý. Þiddete maruz kalanlarla kalmayanlar arasýnda cinsiyet, eðitim durumu, meslek ve psikiyatrik bozukluk taný daðýlýmý açýsýndan anlamlý farklýlýk saptanmadý. Þiddete maruz kalan hastalarýn sosyal iþlevselliklerinin, kiþisel ve sosyal performanslarýnýn, maruz kalmayan hastalardan daha düþük olduðu saptandý.
TARTIÞMA ve SONUÇ: Þiddet, psikiyatri polikliniðine baþvuran hastalarda yaygýndýr. Þiddet, psikiyatrik bozukluklarla iliþkili olduðundan ve iþlevselliði bozduðundan klinisyenler tarafýndan ruhsal deðerlendirme sýrasýnda rutin þekilde sorgulanmalýdýr.

INTRODUCTION: Violence continues to be an important public problem and has negative effects on mental health. In this study, it was aimed to determine the recognition of violence by psychiatric outpatients, the prevalence of violence against psychiatric outpatients and how they are affected by violence.
METHODS: The study included 199 patients who admitted to the general psychiatry outpatient clinic and accepted to participate in the study. The sociodemographic features and detailed assessments of patients on violence were examined with the questionnaire prepared by reviewing the literature on violence.
RESULTS: 78.9% of females and 75.5% of males participated in the study recognized violence physically. Both female and male patients mentioned that "disobedience / irritating behavior" was the most common cause of violence and, “education” was the most obvious factor that can prevent violence. It was found that 56% of the patients (56.8% of females and 55.9% of males) were subjected to violence and, females were subjected to sexual violence more frequently than males. There was no significant difference between patients subjected to violence and those who were not in terms of gender, educational status, occupation, and psychiatric diagnosis. The social functionality, personal and social performances of the patients who were subjected to violence were lower than those who were not subjected to violence.
DISCUSSION AND CONCLUSION: Violence is a common problem among psychiatric outpatients. Because violence is associated with psychiatric disorders and disrupts functionality, clinicians should routinely screen violence during psychiatric evaluation.

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GÝRÝÞ ve AMAÇ: Antipsikotik ilaçlara baðlý yan etkilerin düzenli ve kapsamlý olarak izlenmesi tedavi sürecinin ayrýlmaz bir parçasýdýr. Kullanýcýlar için doldurulmasý kolay olan ve kýsa süre gerektiren özdeðerlendirme ölçeklerine ihtiyaç duyulmaktadýr. Bu çalýþmada Glasgow Antipsikotik Yan Etkilerini Deðerlendirme Ölçeði’nin (GAYEDÖ) Türkçe’ye uyarlanmasý, geçerlilik ve güvenilirlik çalýþmasýnýn yapýlmasý amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Araþtýrma için üç farklý þehirdeki ikinci basamak saðlýk kuruluþunun ruh saðlýðý ve hastalýklarý polikliniðine ayaktan baþvuran, 18 yaþ üstünde, herhangi bir ruhsal bozukluk tanýsý alan ve klozapin dýþýnda en az bir antipsikotik ilacý en az üç aydýr kullanan 297 hasta ve tedavisinde antipsikotik ilaç yer almayan 56 hasta alýndý. Hastalar GAYEDÖ ve Tedaviyle Ýliþkili Ýstenmeyen Olaylarýn Sistematik Ýzlemi’ni (TÝÝOSÝ), klinisyenler ise demografik ve klinik veri formu ve Klinik Global Ýzlenim Ölçeði’ni (KGÝ) doldurdular. GAYEDÖ için açýklayýcý faktör analizi, birlikte geçerlilik, ayýrt edici geçerlilik, iç tutarlýlýk, test – tekrar test güvenilirliði ve tedaviyle deðiþime duyarlýlýk analizleri yapýldý.
BULGULAR: GAYEDÖ’nün yedi faktörden oluþtuðu, TÝÝOSÝ ve KGÝ ile birlikte geçerliliðinin olduðu (sýrasýyla rho = 0.706 ve 0.381, p’ler < 0.001), antipsikotik kullanan ve kullanmayan hastalarý ayýrt edebildiði (U = 14357.50, p < 0.001), iç tutarlýlýðý (Cronbach α = 0.775) ve test – tekrar test güvenilirliðinin olduðu (sýnýfiçi korrelasyon katsayýsý = 0.964, p < 0.001), en az 5 puanlýk bir deðiþim için tedaviyle deðiþime duyarlý olduðu saptandý.
TARTIÞMA ve SONUÇ: Bu sonuçlar GAYEDÖ’nün Türkçe versiyonunun geçerli ve güvenilir olduðunu göstermiþtir. GAYEDÖ ile klinisyenlerin antipsikotik kullanan hastalarýnýn yaþadýðý yan etkileri kýsa sürede, kapsamlý þekilde ve sistematik olarak sorgulamasý, belirtilerin þiddetinin tespit ve takip edebilmesi ve tedavi ile deðiþime yanýtýný deðerlendirmesi mümkün olacaktýr.

INTRODUCTION: Regular and comprehensive follow-up of the side effects of antipsychotic drugs is an essential part of the treatment process. Self-report scales which are user friendly and which do not take too much time to complete are required. The aim of this study was to adapt the Glasgow Antipsychotic Side Effect Scale (GASS) into Turkish, and to evaluate its validity and reliability.
METHODS: For this study, patients over the age of 18 presenting to the outpatient psychiatry clinics of secondary healthcare facilities in three different cities were recruited. Two hundred and ninety-seven of these patients who were on at least one antipsychotic drug except for clozapine for at least three months and who were diagnosed with any psychiatric disorders, and fifty-six patients of them were not on any antipsychotic drug treatment. The patients completed the GASS and the Systematic Monitoring of Adverse events Related to TreatmentS (SMARTS). The clinicians completed a demographic and clinical data form and the Clinical Global Impression Scale (CGI). Exploratory factor analysis was undertaken and concurrent validity, discriminating validity, internal consistency, test – retest reliability, and responsiveness of the GASS were calculated.
RESULTS: Results demonstrated that the GASS consisted of seven factors,that it had concurrent validity with the SMARTS and the CGI (rho=0.706 & 0.381 respectively,p's<0.001),that it could discriminate between patients who were on and who were not on antipsychotics(U=14357.50,p<0.001),that it had internal consistency(Cronbach’s α=0.775) and test–retest reliability(intraclass correlation coefficient=0.964,p<0.001),that it had responsiveness,and that the minimal clinically important difference was 5 points.
DISCUSSION AND CONCLUSION: In conclusion, the Turkish version of the GASS was shown to be a valid and reliable scale. The GASS may enable clinicians to question the side effects experienced by patients who are on antipsychotic drugs comprehensively and systematically in a short time and to identify and follow-up the severity of the symptoms and their response to treatment.

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GÝRÝÞ ve AMAÇ: Bipolar bozuklukta prognozu olumsuz etkileyen dürtüsel davranýþlar ötimik dönemde de devam edebilmektedir. Anksiyete duyarlýlýðý dürtüsel davranýþlara yönelik koruyucu bir faktör olarak görünmektedir. Çalýþmamýzda bipolar bozuklukta anksiyete duyarlýlýðý ile dürtüsel davranýþlar arasýndaki iliþki ve bu iliþkide etkili olabilecek klinik özelliklerin araþtýrýlmasý amaçlanmýþtýr.
YÖNTEM ve GEREÇLER: Çalýþmaya DSM-5’e göre Bipolar Bozukluk tanýlý, ötimik dönemde, komorbid ruhsal hastalýðý bulunmayan 70 hasta ve herhangi bir ruhsal hastalýðý bulunmayan 69 gönüllü dahil edildi. Katýlýmcýlara sosyodemografik veri formu, Hamilton Depresyon Ölçeði, Young Mani Derecelendirme Ölçeði, Algýlanan Stres Ölçeði, Anksiyete Duyarlýlýðý Ýndeksi-3 ve UPPS Dürtüsel Davranýþ Ölçeði uygulandý.
BULGULAR: Hasta grupta algýlanan stres düzeyi, Anksiyete Duyarlýlýðý Ýndeksi toplam, sosyal ve biliþsel alt boyut puanlarý ayrýca Dürtüsel Davranýþ Ölçeði sýkýþýklýk ve heyecan arayýþý alt ölçek puanlarý kontrollere göre yüksek saptandý (her biri için p<0.001). Algýlanan stres düzeyi, Anksiyete Duyarlýlýðý Ýndeksi toplam puaný ve üç alt boyutuyla iliþkili bulundu (her biri için p<0.001). Anksiyete duyarlýlýðýnýn heyecan arayýþý üzerine etkisinde algýlanan stres tam aracý olarak belirlendi.
TARTIÞMA ve SONUÇ: Çalýþmamýzda bipolar bozukluk tanýlý hastalarýn ötimik dönemde saðlýklý kontrollerden algýlanan stres, anksiyete duyarlýlýðý ve dürtüsel davranýþlar yönünden farklý özellikler gösterdiði saptanmýþtýr. Anksiyete duyarlýlýðý ile heyecan arayýþý arasýndaki iliþkide stres düzeyinin aracý etkisinin gösterilmesi; anksiyete duyarlýlýðý ve algýlanan stres düzeyinin artmasýyla dürtüsel eylemlerin azalacaðý hipotezini desteklemektedir.

INTRODUCTION: Impulsive behaviors that adversely affect prognosis in bipolar disorder may persist in the euthymic period. Anxiety sensitivity is a protective factor for impulsive behaviors. In this study, we aimed to investigate the relationship between anxiety sensitivity and impulsive behaviors in bipolar disorder and the clinical features that may be effective in this relationship.
METHODS: Seventy euthymic bipolar patients, according to the DSM-5 criteria, and 69 healthy volunteers with no comorbid mental disorders were included in the study. Sociodemographic data form, the Hamilton Depression Scale, Young Mania Rating Scale, Perceived Stress Scale, Anxiety Sensitivity Index-3, and UPPS Impulsive Behavior Scale were filled out.
RESULTS: The perceived stress level, social and cognitive sub-dimensions, and total scores of the Anxiety Sensitivity Index-3, and scores of the urgency and sensation seeking subscales of the Impulsive Behavior Scale were higher in patients than in healthy controls (p<0.001 for each). The perceived stress level was correlated with the total score of the Anxiety Sensitivity Index-3 and three sub-dimensions (p <0.001 for each). The perceived stress was a full mediator in the relationship between anxiety sensitivity and sensation seeking.
DISCUSSION AND CONCLUSION: In this study, we found that euthymic bipolar patients showed different characteristics in terms of perceived stress, anxiety sensitivity, and impulsive behaviors than healthy controls. The mediating effect of perceived stress on the relationship between anxiety sensitivity and sensation seeking supports the hypothesis that impulsive behaviors will decrease with increased anxiety sensitivity and perceived stress levels.

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GÝRÝÞ ve AMAÇ: Bu çalýþmanýn amacý akademisyenlerin algýladýklarý mobbingin iþ doyumu üzerindeki etkisini araþtýrmak ve bu iliþkide duygusal tükenmenin aracý rolünü analiz etmektir.
YÖNTEM ve GEREÇLER: Akademisyenler tarafýndan algýlanan mobbing, duygusal tükenme ve iþ doyumu arasýndaki iliþkiyi belirlemeye çalýþtýðýmýz bu araþtýrmada öncelikle teorik bir çerçeve çizilmiþ ve çalýþmanýn teorik kýsmýnda sýrasýyla mobbing, duygusal tükenme ve iþ doyumu kavramlarý açýklanmýþtýr. Daha sonra deðiþkenleri araþtýran çalýþmalar gözden geçirilerek araþtýrma modeli ve hipotezler oluþturulmuþtur. Araþtýrma kýsmýnda ise anket tekniði ile bir devlet üniversitesinde görev yapan 90 akademisyenden veri toplanmýþtýr. Araþtýrma verileri ‘Kiþisel Bilgi Formu’, ‘Akademisyenlere Yönelik Mobbing Ölçeði (AYMÖ)’, ‘Minnesota Ýþ Doyum Ölçeði (MÝDÖ)’ ve ‘Maslach Tükenmiþlik Ölçeði (MTÖ)’nin Duygusal Tükenme Alt Ölçeði kullanýlarak toplanmýþtýr. Verilerin analizinde SPSS programýndan yararlanýlmýþtýr. Mobbing algýsýnýn akademisyenlerin iþ doyumuna etkisinde duygusal tükenmenin aracý rolünü tespit etmek üzere korelasyon, basit ve çoklu regresyon analizleri kullanýlmýþtýr.
BULGULAR: Yapýlan analizler sonucunda algýlanan mobbing, duygusal tükenmiþlik ve iþ doyumu deðiþkenleri arasýnda iliþki olduðu ve mobbing algýsýnýn iþ doyumuna etkisinde duygusal tükenmiþliðin kýsmi aracý etkiye sahip olduðu belirlenmiþtir.
TARTIÞMA ve SONUÇ: Sonuç olarak iþ yerinde mobbing algýlayan akademisyenlerin duygusal tükenmiþlik düzeyleri artmakta ve artan duygusal tükenmiþlikle birlikte iþ doyumu düzeyleri azalmaktadýr. Ayrýca, duygusal tükenmenin mobbing ile iþ doyumu iliþkisindeki aracý rolü, bu iliþkide baþka aracý deðiþkenlerin de varlýðýna iþaret etmektedir. Bu nedenle ileride yapýlacak araþtýrmalarda bu araþtýrmadaki modele ek olarak diðer deðiþkenlerin aracý etkisinin araþtýrýlmasý önerilebilir.

INTRODUCTION: The aim of the study is to analyze the effect of perceived mobbing of academicians on job satisfaction and to reveal the moderating effect of emotional exhaustion in this relation.
METHODS: In this research, which we try to determine the relationship between perceived mobbing, emotional exhaustion and job satisfaction, a theoretical framework was first drawn and In the theoretical part, emotional exhaustion, job satisfaction and organizational commitment have been respectively described and explained. Next, studies dealing with the relationship among variables have been analyzed and accordingly research model and hypothesis have been formed. Survey technique was used in the research. Data were collected from 90 academician participated in state university. The data were collected by using the Personal Information Form, Academicians Mobbing Scale (AMS), Minnesota Job Satisfaction Scale (MJSS) and the Emotional Exhaustion Scale (EES) of the Maslach Burnout Inventory (MBI). The questionnaire was applied to the collection of data and SPSS program was used in the analysis of the data. Corelation, simple and multiple regression analyzes were used to determine the mediating role of emotional exhaustion in the effect of perceived mobbing on job satisfaction.
RESULTS: According to results, it was determined that there is a relationship between, perceived mobbing, emotional exhaustion and job satisfaction and in the effect of perceived mobbing on job satisfaction, emotional exhaustion partly mediated.
DISCUSSION AND CONCLUSION: As a result, the emotional exhaustion levels of the academicians who perceive mobbing in work place are increasing. Job satisfaction levels decrease with increasing emotional burnout. Additionally,. The mediator role of emotional exhaustion in the relationship between mobbing and job satisfaction indicates the presence of other mediating variables in this relationship. For this reason, in addition to the model in this research, it can be suggested to investigate the mediator effect of other variables in future research.

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GÝRÝÞ ve AMAÇ: Ergenlerde aleksitimi kiþilik özelliði ile kaygý düzeyi arasýndaki iliþkide, düþünce eylem kaynaþmasýnýn (DEK) aracý etkisini incelemektir.
YÖNTEM ve GEREÇLER: Ýstanbul ilinde 11-17 yaþ aralýðýnda 985 ergen (%55.2 kýz, s=544, %44.8 erkek s=441) çalýþmaya dahil edilmiþtir. Sosyodemografik bilgi formu, 20 soruluk Toronto aleksitimi ölçeði (TAÖ-20), çocuklar için düþünce eylem kaynaþmasý ölçeði (DEK-Ç) ve çocuklar için sürekli kaygý envanteri (SKE-Ç) uygulanmýþtýr. Cinsiyetler arasý ölçek puanlarý baðýmsýz örneklem t testi ile karþýlaþtýrýlmýþtýr. Ölçekler arasý korelasyonlar Pearson momentler çarpýmý korelasyon testi ile analiz edilmiþtir. DEK-Ç puanlarýnýn, aleksitimi ile kaygý düzeyi arasýndaki etkisi mediasyon analizi ile deðerlendirilmiþtir. Modele cinsiyet ile yaþ kontrol deðiþkenleri olarak eklenmiþtir.
BULGULAR: Kýz cinsiyette TAÖ-20 ve SKE-Ç toplam puanlarý, erkek katýlýmcýlara oranla anlamlý olarak daha yüksek bulunmuþtur. TAÖ-20 toplam puanlarý, SKE-Ç puanlarý ile pozitif yönde güçlü korelasyon göstermektedir. TAÖ-20 ile DEK-Ç puanlarý arasýnda ve DEK-Ç ile SKE-R puanlarý arasýnda zayýf düzey korelasyon bulunmaktadýr. Mediasyon analizine göre, aleksitimi düzeyi direkt olarak yüksek kaygý düzeyi ile iliþkilidir. DEK, aleksitimi ile kaygý arasýnda istatistiksel anlamlý olarak aracý etkiye sahiptir.
TARTIÞMA ve SONUÇ: Ergen yaþ grubunda aleksitimi kiþilik özellikleri, kaygý düzeyini arttýrabilmektedir; DEK, aleksitimi ve kaygý sorunlarý arasýndaki iliþkide aracý rol oynamaktadýr. Aleksitimi kiþilik özelliðine sahip ergenlerde, DEK’e yönelik terapötik müdahale yöntemlerinin uygulanmasý, kaygý sorunlarýnýn azaltýlmasýnda faydalý olabilir.

INTRODUCTION: To investigate the mediation effect of thought action fusion (TAF) in the relationship between the alexithymia and trait anxiety levels.
METHODS: 985 adolescents ( %55.2 female, n=544, %44.8 male, n=441) between the ages of 11-17 were included in this study. The socio-demographic questionnaire, 20 item Toronto alexithymia scale (TAS-20), thought action fusion inventory for children (TAFIC) and trait anxiety inventory for children (TAI-C) were used. In terms of gender, the mean scores of the scales were compared by independent sample t test. The correlations between the scales were analyzed by Pearson product moment correlation analysis. The mediation effect of TAFIC scores on the relationship between the alexithymia and trait anxiety levels were tested by mediation analyis. The gender and age variables were included in the model as covariants.
RESULTS: The mean scores of TAS-20 and TAI-C were higher in females than males, significantly. There were strong correlations between TAS-20 total scores and TAI-C scores. There were weak correlations between TAS-20 and TAFIC total scores; and TAFIC total and TAI-C scores. The mediation analysis indicated that alexithymia levels are directly associated with high anxiety levels. TAF has mediation effect on the relationship between the alexithymia and anxiety levels.
DISCUSSION AND CONCLUSION: The alexithymia personality traits may improve anxiety levels in adolescent population, and TAF plays a mediator role in this relationship. It is suggested that, using associated therapeutic interventions focusing on TAF problems may improve the anxiety problems in adolescents presenting with alexithymia personality traits.

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GÝRÝÞ ve AMAÇ: Bu çalýþmanýn amacý, Dokuz Tip Mizaç Modeli (DTMM) odaklý bir bakýþ açýsýyla MDB ve MDB belirteçleri ile mizaç ve kiþilik özellikleri arasýndaki iliþkilerin incelenmesidir.
YÖNTEM ve GEREÇLER: Çalýþmaya; 18-60 yaþ aralýðýnda, en az 8 hafta iyilik döneminde olup tedavileri devam eden, 208 MDB’li ve MDB’li grupla eþlenmiþ 203 saðlýklý birey dahil edildi. Tüm katýlýmcýlara sosyo-demografik veri formu, Dokuz Tip Mizaç Ölçeði (DTMÖ) ve Mizaç Karakter Envanteri (MKE), MDB’li bireylere ayrýca Hamilton Depresyon Derecelendirme Ölçeði (HDDÖ) uygulandý. MDB belirleyicileri deðerlendirmeleri ise izlem dosyalarýndan alýnan bilgiler üzerinden yapýldý.
BULGULAR: Dokuz Tip Mizaç (DTM)1, DTM2, DTM3, DTM4, DTM6 ve DTM8, Psikobiyolojik Kiþilik Modeli (PKM)’nin boyutlarýndan iþbirliði yapma (ÝB), sebat etme (SE), zarardan kaçýnma (ZK) ve kendini yönetme (KY) MDB ile iliþkili bulundu. MDB belirleyicileri açýsýndan; bunaltýlý-sýkýntý özellik gösterenler DTM2, DTM3, DTM6, DTM9; melankoli özellikleri gösterenler DTM1, DTM5 ve DTM6 ve mevsimsel özellik gösterenler DTM4, karma özellik gösterenler DTM4, DTM7 ve atipik özellikler gösterenler DTM5, DTM7, DTM9 mizaç tipleriyle iliþkili bulunmuþtur.
TARTIÞMA ve SONUÇ: Kiþiliðin yapýsal temelini oluþturan mizacýn, MDB hastalarýnda hem tanýda hem de semptomatolojinin bireye özgü tanýnmasýnda etkili bir parametre olduðu görülmektedir. Ayrýca MDB belirteçlerinin tanýmlanmasýnda mizacýn ayrýþtýrýcý bir etken olabildiði söylenebilir. Gelecekte yapýlacak çalýþmalarla, mizaç odaklý taný ve tedavi stratejilerinin geliþtirilmesinin, uygulamaya fayda saðlayabileceði düþünülmektedir.

INTRODUCTION: The aim of this study is to investigate the relationship of Major Depressive Disorder (MDD) and MDD specifiers with temperament and personality traits with a perspective focused on Nine Type Temperament Model (NTTM).
METHODS: 203 healthy participants who are matched with the 208 MDD participants group between 18-60 years old and in at least eight weeks remission period and treatment in progress, without an additional diagnosis were included in the study. Socio-demographic data form, Nine Types of Temperament Scale (NTTS) and Temperament Character Inventory (TCI) were applied to all participants, and in addition, Hamilton Depression Rating Scale (HDRS) were applied to the subjects with MDD. MDD specifiers were evaluated using follow-up data files.
RESULTS: According to results, both Nine Type Temperament (NTT) Model’s types, which are NTT1, NTT2, NTT3, NTT4, NTT6 and NTT8, and Psychobiological Personality Model’s dimensions which are consisted of the cooperation, persistence, harm avoidance and self-management were found to be associated with MDD. From the point of MDD determinants; anxiety-distressing characteristics are associated with NTM2, NTM3, NTM6, NTM9; melancholy characteristics is concerned with NTT1, NTT5 and NTT6; seasonal characteristics are related to NTT4; mixed features are relevant with NTT4 and NTT7; and atypical features are associated with NTT5, NTT7, NTT9. As a result, MDD determinants are found to be associated with temperament types which are coming from NTTM.
DISCUSSION AND CONCLUSION: It is seen that temperament, which constitutes the structural basis of personality, is an effective parameter both in the diagnosis and in the individual-specific recognition of symptomatology in MDD patients. In addition, it can be said that temperament can be a discriminating factor in defining MDD specifiers. The development of temperament-oriented diagnosis and treatment strategies in future studies may be beneficial for the practice.

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GÝRÝÞ ve AMAÇ: Çalýþmanýn amacý, Saðlýklý ve dengeli beslenmek amacýyla hipnoterapi seansýna baþvuran obezite hastalarýnda, uygulanan hipnoterapinin hastalarýn depresyon ve anksiyete düzeylerine olan etkisini deðerlendirmektir.
YÖNTEM ve GEREÇLER: Çalýþma grubu; Numune Hastanesi Psikiyatri polikliniðine baþvuran, gönüllü olarak araþtýrmaya katýlmayý kabul eden, Beden Kitle Ýndexleri 30 ve üstü olan, 10 haftalýk seansý tamamlayan toplam 60 bireyden oluþtu. Katýlýmcýlara ilk önce; bilgi formu düzenlendi ve Beden Kitle Ýndexleri belirlendi. Her katýlýmcýya seansa baþlamadan önce beck depresyon ve beck anksiyete ölçeði uygulandý. Sonrasýn da hafta da 1 seans olmak üzere 10 hafta boyunca hipnoterapi seansý uygulandý. On haftalýk seans bitiminde tekrar Beden Kitle Ýndexleri belirlenip Beck Depresyon ve Beck Anksiyete Ölçeði uygulandý. Terapi baþlangýcý ve bitimindeki Beden Kitle Ýndexlerinin, Beck Depresyon ve Beck Anksiyete Ölçeklerinin karþýlaþtýrýlmasý yapýlarak hipnoterapinin etkinliði deðerlendirildi.

BULGULAR: Beden Kitle Ýndexleri, Beck Depresyon Ölçeði ve Beck Anksiyete Ölçeði puanlarýnýn hipnoterapi öncesi ve sonrasý karþýlaþtýrýlmasýnda; anlamlý deðiþiklikler saptandý (p<0.001). Ayrýca Beck Depresyon Ölçeði ile Beck Anksiyete Ölçek puanlarý arasýnda anlamlý pozitif bir korelasyonun olduðu da tespit edildi (p<0.001).


TARTIÞMA ve SONUÇ: Bu araþtýrma obezite tedavisinde uygulan hipnoterapinin, obezite hastalarýndaki depresyon ve anksiyetenin azalmasýnda etkili olduðunu gösterdi. Bu alanda kontrol grubu oluþturarak, daha fazla kiþide ve daha uzun vadede etkinliðini inceleyecek yeni çalýþmalara ihtiyaç vardýr.

INTRODUCTION: The purpose of the present study was to investigate the effect of hypnotherapy on depression and anxiety levels of obese patients who were admitted to hypnotherapy sessions for healthy and balanced diet.

METHODS: Methods: The study sample consisted of 60 individuals who presented to the Psychiatry Polyclinic of Numune Hospital, who volunteered to participate in the study, whose Body Mass Index was 30 and above and who completed 10-week hypnotherapy session. Firstly, the participants’ body mass indexes were determined after their “personal information forms” were filled in. Before the hypnotherapy sessions were started, the Beck Depression Inventory and Beck Anxiety Inventory were administered to each participant. After that, hypnotherapy sessions were performed for 10 weeks, one session per week. At the end of a 10-week hypnotherapy session, the participants’ Body Mass Indexes were determined again, and the Beck Depression Inventory and Beck Anxiety Inventory were re-administered. Then the effectiveness of hypnotherapy was evaluated by comparing the pre- and post-therapy Body Mass Indexes, and the scores obtained from the Beck Depression Inventory and Beck Anxiety Inventory.

RESULTS: The comparison of the pre- and post-therapy Body Mass Indexes, and the scores obtained from the Beck Depression Inventory and Beck Anxiety Inventory demonstrated significant differences (p<0.001). There was a significant positive correlation between the scores obtained from the Beck Depression Inventory and those obtained from Beck Anxiety Inventory (p <0.001).

DISCUSSION AND CONCLUSION: The present study demonstrated that the use of hypnotherapy in the treatment of obesity was effective in reducing depression and anxiety levels of obese patients. It is recommended that future studies should be performed to investigate the long-term effects of the hypnotherapy and consist of larger samples including a control group.

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Introduction: This article performs a systemic review of psychometric properties and factor structure of Compulsive Internet Use Scale (CIUS), the scale for assessing Internet addiction behavior in clinic and research fields.
Methods: Studies measuring psychometric properties and factor structure of CIUS (original version) were searched through MEDLINE in PubMed, SCOPUSE, Pub Psych, google scholar and SID & Iranmedex (Iranian database). A total of 18 studies(24samples) including 44,198subjects were reviewed in our study.
Results: Based on meta-analysis for internal consistency, the pooled Cronbach’s alpha coefficient from all study was 0.47(95percent confidence interval [CI], 0.46-0.49). Based on meta-analysis for internal consistency adolescence subgroup was 0.48 (95percent confidence interval [CI], 0.45–0.51), and addicted to behavior addiction subgroup was 0.48 (95 percent CI, 0.44–0.51), in general population subgroup was 0.47(95percent confidence interval [CI], 0.42-0.53), in university student subgroup was 0.47(95percent confidence interval [CI], 0.43-0.51), in internet user was 0.45(95percent confidence interval [CI], 0.43-0.47), by cultural of country for collectivistic society was 0.49(95percent confidence interval [CI], 0.46-0.52), and individualistic societies was 0.46(95percent confidence interval [CI], 0.44-0.47) and based quality assessment subgroup for study was 0.47(95percent confidence interval [CI], 0.46-0.49).
Conclusion: future studies should be conducted on multiethnic population and cross-cultural designee. Future studies should be developed and reported based on COSMIN checklist.

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Þizofreni pozitif, negatif belirtiler, biliþsel bozulma, dezorganizsayon ve benzeri boyutlardan oluþan ve bu boyutlarýn farklý düzeylerde kesiþimi nedeniyle farklý görünümlerle karþýmýza çýkan bir bozukluktur. Þizofreni benzeri tablolarýn tanýmlanmasý ilk olarak þizofreni hastalarýnýn ailelerinde psikoz benzeri belirtilerin bir yýðýlým gösterdiði izlenimine dayanmaktadýr. Sonrasýnda yapýlan çalýþmalarda paranoid, þizoid ve þizotipal kiþilik bozukluklarý bu spektrumda þizofreniyle karþýlaþtýrýlarak incelenmiþtir. Özellikle þizotipal kiþilik bozukluðunun bir kiþilik bozukluðu olmaktan çok farklý þizotipi boyutlarýnýn bir arada ve yoðun olarak görüldüðü, ilerleyici olmayan bir þizofreni spektrum bozukluðu olduðu düþüncesi giderek baskýn hale gelmektedir. Kiþilik bozukluklarý içinde þizofteni ile en fazla genetik ortaklýðý bulunan þizotipal kiþilik bozukluðudur. Þizotipi terimi ilk kez þizofreni benzeri psikoz fenotipi olarak tanýlanmýþtýr. Günümüze kadar yapýlan çalýþmalarla þizotipinin, týpký þizofreni gibi farklý boyutlarýnýn olduðu ve bu boyutlarýn klinik olmayan populasyonda ve psikoz riski altýndaki bireylerde yaygýn olarak karþýlýðýnýn olduðu gösterilmiþtir. Ayný zamanda þizofreni ve þizotipinin birbiriyle iliþkili boyutlarýnýn benzer nörobiyolojik temelleri olduðu bulunmuþtur. Tanýmý gereði þizofreni prodromu ancak þizofreni geliþmiþ hastalarda geriye yönelik adý konabilecek bir durumdur. Bu nedenle þizotipal kiþilik bozukluðu ve yüksek þizotipi þizofreni prodromunu yansýtmaktan ziyade yelpazenin içinde yer alan bir yatkýnlýk göstergesidir. Psikoz etiyopatogenezinin aydýnlatýlmasý, þizofreninin erken tanýsý, duyarlýlaþtýrýcý etkenlere müdahale ve psikotik kýrýlmanýn önlenmesi açýsýndan sýnýrda yer alan bu olgularýn tanýmlanmasý önem taþýmaktadýr.

Schizophrenia is a disorder that consists of positive, negative symptoms, cognitive impairment, disorganization and various dimensions and manifested as several clinical appearances because of different intersections of these dimensions at different levels. The description of the schizophrenia-like clinical picture is based primarily on the finding that psychosis-like symptoms have accumulated in families of patients with schizophrenia. The following studies have examined paranoid, schizoid and schizotypal personality disorders in this spectrum by comparing them to schizophrenia. The idea intensely becomes more dominant in the literature that especially schizotypal personality disorder (SPD) is a non-progressive schizophrenia spectrum disorder in which different dimensions of schizotypy are seen together rather than a personality disorder. Among the personality disorders, SPD has the strongest genetic relationship with schizophrenia. The term schizotypy was first described as a schizophrenia-like psychosis phenotype. To date, studies have shown schizotypy has different dimensions, such as schizophrenia, and that reflections of these dimensions are common in non-clinical populations and individuals at risk for psychosis. At the same time, several studies found related dimensions of schizophrenia and schizotypy have similar neurobiological bases. As per the definiton of prodrome is a condition can only be defined retrospectively in patients with schizophrenia. Therefore, schizotypal personality disorder and high schizotypy are predisposition indicators within the spectrum rather than reflecting the schizophrenia prodrome. Identifying of these borderline cases is important for uncovering etiopathogenesis of psychosis, early diagnosis of schizophrenia, intervention to predisposing factors and prevention of psychotic break.

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Amaç: Randomize plasebo kontrollü çalýþmalar (RKÇ) týbbi tedavilerin etkinliðini ve güvenliðini test etmekte çok önemlidir. Çocukluk çaðý bipolar bozukluðun manik epizodunda yapýlmýþ çok fazla RKÇ bulunmamaktadýr. Bu çalýþmalardaki yüksek plasebo yanýtý pratikte gerçek ilaç yanýtlarýnýn tespitinde sorunlara neden olmaktadýr. Bu nedenle ilaç ve plasebo yanýtýnýn belirleyicilerini analiz etmek ileride daha güvenilir RKÇ'ler yürütebilmek için önemli olmaktadýr.
Metod: PubMed, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials ve bazý diðer arama motorlarýnda geniþ bir tarama yapýldý. Bipolar bozukluk manik epizod ve eþlik eden semptomlar(DEHB, irritabilite vb.) çalýþmaya dahil edildi. Cinsiyet, etnisite ya da baþlangýç þiddeti ile ilgili bir sýnýrlama getirilmedi. 18 yaþýn üzerinde katýlýmcý olan çalýþmalar dýþlandý. Plasebo ve ilaç etki büyüklüklerini hesaplamak için random etki büyüklüðü modeli kullanýldý.
Bulgular: Toplamda 1974 katýlýmcý ve 11 çalýþma meta-analize dahil edildi. Risperidon ilaç kolunda en yüksek etki büyüklüðüne sahipti. Meta-regresyonda merkezlerin sayýsý ve katýlýmcýlarýn sayýsý yüksek plasebo yanýtýyla iliþkili bulundu. Ýlaç yanýtý etkileyen herhangi bir deðiþken bulunmadý. Meta-analizde herhangi bir yayýn yanlýðý tespit edilmedi.
Sonuç: Çalýþmada eriþkin çalýþmalarý ile benzer sonuçlar bulundu. Randomize edilen katýlýmcý sayýsýný ve katýlan merkez sayýsýný modifye etmek plasebo yanýtýný sýnýrlayabilir ve RKÇ'lerin etkinliðini geliþtirebilir ve ilaç-plasebo farklýlýklarýný arttýrabilir.

Objective: Randomized placebo controlled trials (RCT) are very important for testing efficacy and safety of a medical treatment. There is no too much RCT`s in childhood bipolar disorder manic episode. In these trials, high placebo response poses a problem for the definition of real drug responses in practice. Therefore, analysis of predictors of drug and placebo response are important for conducting more reliable RCT`s in the future.
Method: Comprehensive search conducted in PubMed, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL) and some other electronic databases. Studies including participants with Bipolar Disorder manic episode and associated symptoms (e.g ADHD, irritability) included. There was no restriction in terms of sex, ethnicity or initial severity. Participants over age 18 were excluded. Random effect size model was used for calculate effect sizes for placebo and drugs.
Results: A total of 1974 participants and 11 studies were included in the meta-analysis. Risperidone was highest effect size among drug arms. Number of the sites and number of the participants were associated with higher placebo response in meta-regression. We did not find any variable had an impact on drug response. There was no any publication bias in this meta-analysis.
Conclusion: We found similar results as adult studies. Modifying number of the sites or ramdomized sample size may limit placebo response and could improve the efficacy of RCT`s and enhance drug-placebo contrasts.

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